GLP-1s and Hormone Therapy: What the Science Says and Why It Matters
Dr. Rocio Salas-Whalen
You’ve heard the headlines. Ozempic, Wegovy, GLP-1s. But what is actually happening inside your body when you take them? In this episode, Tamsen sits back down with triple board-certified endocrinologist Dr. Rocio Salas-Whalen to get real, science-backed answers. They break down how these medications work, why muscle loss is a real risk, and how hormone therapy plays a role in your overall metabolic health.
This conversation goes beyond quick fixes and tackles what sustainable, medically informed weight loss really looks like. It’s about body composition, long-term health, and understanding the emotional impact of a changing body.
They talk about:
-How GLP-1 medications like Ozempic and Wegovy work in the gut, brain, and pancreas
-The connection between GLP-1s, visceral fat, and insulin resistance
-Why you may be losing muscle instead of fat if not monitored properly
-What "Ozempic butt" really means and how to prevent it
-The truth about hair loss, protein intake, and rapid weight loss
-When to combine GLP-1s with hormone therapy and how to approach it safely
-Why weight loss isn't just physical and the emotional impact many women aren't prepared for
01:24 - Why Dr. Rocio Salas-Whalen Wanted to Address Misinformation
03:19 - What Is a GLP-1?
05:07 - How do GLP-1s Work in our Bodies?
07:13 - GLP-1s and Anti-Inflammatory Effects
08:22 - The Fascinating Origin of GLP-1s
12:46 - What Is Microdosing and Is It Effective?
14:45 - Oral vs. Injectable GLP-1s: What You Need to Know
16:01 - Why Diet Still Matters on GLP-1s (And What to Eat)
17:20 - Are GLP-1s Really “Vanity” Drugs? A Reframe
18:01 - Combining GLP-1s with Hormone Therapy in Midlife
22:06 - Can You Lose Belly Fat Without Medication or Hormones?
23:06 - The Real Causes of Midlife Weight Gain
25:28 - Why Motivation Often Comes After Weight Loss
26:16 - Can You Come Off GLP-1s Without Gaining the Weight Back?
28:00 - Psychological & Social Side Effects of Weight Loss No One Talks About
29:18 - Excess Skin, Body Image & What Happens After You Lose the Weight
30:07 - The Common Side Effects of GLP-1s
31:58 - The Future of GLP-1s
Dr. Rocio is the founder of New York Endocrinology and a leading voice in obesity medicine. Her upcoming book will cover everything she shares in her practice and more.
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Medical Disclaimer:
The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional regarding any medical concerns or treatment options. The views expressed by guests are their own and do not necessarily reflect those of The Tamsen Show.
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I’m an Emmy Award-winning journalist, filmmaker, author, speaker, certified integrative nutrition coach, and passionate menopause advocate.
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